Fluidization characterization in the ConSigma 25 dryer via process data – A method of advanced quality assurance in continuous manufacturing

Wet granulation lines in pharmaceutical manufacturing facilities typically comprise a dryer that removes the excess moisture content after wet granulation. In this study, semi-continuous installed ConsiGma 25 line was investigated. The goal to highlight specific characteristics of type dryer, utilizing available process data and corresponding obtained via material characterization. This paper addresses typical effects issues associated with dryer’s setup operation (e.g., unexpected cell temperature profiles, air flow on granule properties, variations between cells). Since many situations liquid-to-solid ratio is based properties granules step, selection inlet rate as well overall throughput (affecting fill level dryer) are particular interest from practical point view. discusses these provides suggestions how address them when setting up process. A novel approach for characterizing fluidization inside by means quantifying “smoothness” profile proposed. should be viewed hands-on guideline, which highlights possible pitfalls during offers solutions.